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477781-69-4

477781-69-4 structure
477781-69-4 structure
  • Name: Benzyl-PEG4-MS
  • Chemical Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
  • CAS Number: 477781-69-4
  • Molecular Formula: C16H26O7S
  • Molecular Weight: 362.438
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-20 18:10:57
  • Modify Date: 2024-01-29 14:23:11
  • Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Synonyms 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
2,5,8,11-Tetraoxatridecan-13-ol, 1-phenyl-, methanesulfonate
Benzyl-PEG4-MS
Description Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 497.1±40.0 °C at 760 mmHg
Molecular Formula C16H26O7S
Molecular Weight 362.438
Flash Point 254.5±27.3 °C
Exact Mass 362.139923
LogP 0.42
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.502