477781-69-4

477781-69-4 structure

Name: Benzyl-PEG4-MS
Chemical Name: 1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
CAS Number: 477781-69-4
Molecular Formula: C₁₆H₂₆O₇S
Molecular Weight: 362.438
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-20 18:10:57
Modify Date: 2024-01-29 14:23:11
Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate
Synonyms	1-Phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate 2,5,8,11-Tetraoxatridecan-13-ol, 1-phenyl-, methanesulfonate Benzyl-PEG4-MS

Description	Benzyl-PEG4-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562