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1260092-44-1

1260092-44-1 structure
1260092-44-1 structure
  • Name: Boc-NH-PEG1-CH2CH2COOH
  • Chemical Name: 3-[2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]propanoic acid
  • CAS Number: 1260092-44-1
  • Molecular Formula: C10H19NO5
  • Molecular Weight: 233.262
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-06-30 22:29:31
  • Modify Date: 2025-08-25 13:50:15
  • Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].

Name 3-[2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]propanoic acid
Synonyms Propanoic acid, 3-[2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]-
3-[2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)ethoxy]propanoic acid
MFCD22574796
t-Boc-N-amido-PEG1-acid
t-boc-N-amido-PEG1-propionic acid
Description Boc-NH-PEG1-CH2CH2COOH is a cleavable (1 unit PEG) ADC linker and also a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of antibody-drug conjugates (ADCs) or PROTACs[1][2].
Related Catalog
Target

PEGs

Alkyl/ether

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Alex Cortez, et al.Antibody conjugates comprising toll-like receptor agonist and combination therapies. WO2018198091A1.

[2]. Darren H. Wakefield, et al. Poly(vinyl ester) Polymers for In Vivo Nucleic Acid Delivery. US20130121954A1.

Density 1.1±0.1 g/cm3
Boiling Point 385.0±27.0 °C at 760 mmHg
Molecular Formula C10H19NO5
Molecular Weight 233.262
Flash Point 186.7±23.7 °C
Exact Mass 233.126328
LogP 0.93
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.463
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