1365655-91-9

1365655-91-9 structure

Name: Boc-NH-PEG2-CH2CH2COOH
Chemical Name: 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
CAS Number: 1365655-91-9
Molecular Formula: C₁₂H₂₃NO₆
Molecular Weight: 277.314
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-16 18:46:12
Modify Date: 2025-08-25 20:28:53
Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

Name	2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
Synonyms	2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid 3,8,11-Trioxa-5-azatetradecan-14-oic acid, 2,2-dimethyl-4-oxo- MFCD22056304 N-Boc-3-[2-(2-aminoethoxy)ethoxy]propionic Acid

Description	Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.