Boc-NH-PEG2-CH2CH2COOH

Modify Date: 2024-01-09 23:36:35

Boc-NH-PEG2-CH2CH2COOH Structure
Boc-NH-PEG2-CH2CH2COOH structure
Common Name Boc-NH-PEG2-CH2CH2COOH
CAS Number 1365655-91-9 Molecular Weight 277.314
Density 1.1±0.1 g/cm3 Boiling Point 429.9±35.0 °C at 760 mmHg
Molecular Formula C12H23NO6 Melting Point N/A
MSDS N/A Flash Point 213.8±25.9 °C

 Use of Boc-NH-PEG2-CH2CH2COOH


Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].

 Names

Name 2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
Synonym More Synonyms

 Boc-NH-PEG2-CH2CH2COOH Biological Activity

Description Boc-NH-PEG2-CH2CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 429.9±35.0 °C at 760 mmHg
Molecular Formula C12H23NO6
Molecular Weight 277.314
Flash Point 213.8±25.9 °C
Exact Mass 277.152527
LogP 0.57
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.465

 Synonyms

2,2-Dimethyl-4-oxo-3,8,11-trioxa-5-azatetradecan-14-oic acid
3,8,11-Trioxa-5-azatetradecan-14-oic acid, 2,2-dimethyl-4-oxo-
MFCD22056304
N-Boc-3-[2-(2-aminoethoxy)ethoxy]propionic Acid
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