1454619-13-6

1454619-13-6 structure

Name: PU-H54
Chemical Name: 8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine
CAS Number: 1454619-13-6
Molecular Formula: C₁₈H₁₉N₅S
Molecular Weight: 337.442
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2018-06-22 14:57:46
Modify Date: 2024-01-10 19:10:34
PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1].

Name	8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine
Synonyms	8-[(2,4-dimethylphenyl)sulfanyl]-3-pent-4-yn-1-yl-3H-purin-6-amine 3H-Purin-6-amine, 8-[(2,4-dimethylphenyl)thio]-3-(4-pentyn-1-yl)- 8-((2,4-Dimethylphenyl)thio)-3-(pent-4-yn-1-yl)-3H-purin-6-amine 8-[(2,4-Dimethylphenyl)sulfanyl]-3-(4-pentyn-1-yl)-3H-purin-6-amine PU-H54

Description	PU-H54, a Grp94-selective inhibitor, can be used for the research of breast cancer. Hsp90 chaperone family, comprised in humans of four paralogs, Hsp90α, Hsp90β, Grp94 and Trap-1, has important roles in malignancy[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Pallav D Patel, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9(11):677-84.