159600-82-5

159600-82-5 structure

Name: (p-Iodo-Phe7)-ACTH (4-10)
Chemical Name: L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine
CAS Number: 159600-82-5
Molecular Formula: C₄₄H₅₈IN₁₃O₁₀S
Molecular Weight: 1087.982
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-25 15:07:30
Modify Date: 2024-01-15 20:47:03
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1].

Name	L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine
Synonyms	Glycine, L-methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophyl- L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine

Description	(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
In Vitro	(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1]. [Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2].
In Vivo	(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1]. Animal Model: Male Wistar rats (150 g)[1] Dosage: 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not Administration: Intracerebroventricular injection; one week prior to the experiment Result: Didn’t induce excessive grooming behavior by single dose. Inhibited the induction of excessive grooming behavior by a-MSH.