(p-Iodo-Phe7)-ACTH (4-10)
Modify Date: 2024-01-15 20:47:03
(p-Iodo-Phe7)-ACTH (4-10) structure
|
Common Name | (p-Iodo-Phe7)-ACTH (4-10) | ||
|---|---|---|---|---|
| CAS Number | 159600-82-5 | Molecular Weight | 1087.982 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C44H58IN13O10S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (p-Iodo-Phe7)-ACTH (4-10)(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1]. |
| Name | L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine |
|---|---|
| Synonym | More Synonyms |
| Description | (p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1]. |
|---|---|
| Related Catalog | |
| In Vitro | (p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1]. [Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2]. |
| In Vivo | (p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1]. Animal Model: Male Wistar rats (150 g)[1] Dosage: 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not Administration: Intracerebroventricular injection; one week prior to the experiment Result: Didn’t induce excessive grooming behavior by single dose. Inhibited the induction of excessive grooming behavior by a-MSH. |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C44H58IN13O10S |
| Molecular Weight | 1087.982 |
| Exact Mass | 1087.319458 |
| LogP | 0.85 |
| Index of Refraction | 1.711 |
| Glycine, L-methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophyl- |
| L-Methionyl-L-α-glutamyl-L-histidyl-4-iodo-L-phenylalanyl-L-arginyl-L-tryptophylglycine |