581066-04-8

581066-04-8 structure

Name: Azido-PEG4-Boc
Chemical Name: 2-Methyl-2-propanyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate
CAS Number: 581066-04-8
Molecular Formula: C₁₅H₂₉N₃O₆
Molecular Weight: 347.407
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-08 14:21:50
Modify Date: 2025-08-25 13:48:05
Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-Methyl-2-propanyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate
Synonyms	2-Methyl-2-propanyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate 3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-azido-, 1,1-dimethylethyl ester Azido-PEG5-t-butyl ester

Description	Azido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562