883976-12-3

883976-12-3 structure

Name: M8 B hydrochloride
Chemical Name: N-(2-Aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-2-thiophenecarboxamide hydrochloride (1:1)
CAS Number: 883976-12-3
Molecular Formula: C₂₂H₂₅ClN₂O₃S
Molecular Weight: 432.964
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2018-06-08 18:03:07
Modify Date: 2024-01-23 07:44:45
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1].

Name	N-(2-Aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-2-thiophenecarboxamide hydrochloride (1:1)
Synonyms	MFCD27978374 N-(2-Aminoethyl)-N-[4-(benzyloxy)-3-methoxybenzyl]-2-thiophenecarboxamide hydrochloride (1:1) 2-Thiophenecarboxamide, N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-, hydrochloride (1:1)

Description	M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb)[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Metabolic Disease
Target	TRPM8
In Vitro	M8-B (0-100 µM) 以剂量依赖性方式抑制最大 Ca2+ 摄取来抑制 TRPM8 通道活性[1]。
In Vivo	M8-B (6 mg/kg; i.v. or i.p.) 降低大鼠和小鼠的深部体温[1]。 Animal Model: Trpm8+/+ rats and mice[1] Dosage: 6 mg/kg Administration: I.v. or i.p. Result: Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8−/− mice.
References	[1]. Almeida MC, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32(6):2086-99.

RIDADR	NONH for all modes of transport