887923-50-4
887923-50-4 structure
- Name: Gambogic acid B
- Chemical Name: (2Z)-4-[(1S,2S,8R,15S,16S,17S,19R)-16-Ethoxy-12-hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11-tetraen-19-yl]-2-methyl-2-butenoic acid
- CAS Number: 887923-50-4
- Molecular Formula: C40H50O9
- Molecular Weight: 674.820
- Catalog: Research Areas Cancer
- Create Date: 2018-06-18 12:24:50
- Modify Date: 2024-02-05 15:46:42
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Gambogic acid B is an active compound. Gambogic acid B can be isolated from the resin of Garcinia hanburyi.. Gambogic acid B has cytotoxicity against A549, HCT116 and MDA‑MB‑231 cells with IC50 values of 1.60 μM, 6.88 μM and 0.87 μM, respectively[1].
| Name | (2Z)-4-[(1S,2S,8R,15S,16S,17S,19R)-16-Ethoxy-12-hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11]docosa-4(13),5,9,11-tetraen-19-yl]-2-methyl-2-butenoic acid |
|---|---|
| Synonyms |
2-Butenoic acid, 4-[(1R,3aS,5S,6S,6aS,11R,14aS)-6-ethoxy-3a,4,5,6,6a,7-hexahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-methyl-, (2Z)-
(2Z)-4-[(1S,2S,8R,15S,16S,17S,19R)-16-Ethoxy-12-hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo[15.4.1.02,15.02,19.04,13.06,11 ]docosa-4(13),5,9,11-tetraen-19-yl]-2-methyl-2-butenoic acid |
| Description | Gambogic acid B is an active compound. Gambogic acid B can be isolated from the resin of Garcinia hanburyi.. Gambogic acid B has cytotoxicity against A549, HCT116 and MDA‑MB‑231 cells with IC50 values of 1.60 μM, 6.88 μM and 0.87 μM, respectively[1]. |
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| Related Catalog | |
| Target |
IC50: 1.60 μM (A549 cell); 6.88 μM (HCT116 cell); 0.87 μM (MDA‑MB‑231 cell)[1] |
| In Vitro | Gambogic acid B 对 A549、HCT116 和 MDA-MB-231 细胞具有细胞毒性， IC50 值分别为 1.60 μM、6.88 μM 和 0.87 μM[1]。 |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 815.7±65.0 °C at 760 mmHg |
| Molecular Formula | C40H50O9 |
| Molecular Weight | 674.820 |
| Flash Point | 247.5±27.8 °C |
| Exact Mass | 674.345459 |
| LogP | 11.27 |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| Index of Refraction | 1.606 |