1259314-65-2

1259314-65-2 structure

Name: JP1302 dihydrochloride
Chemical Name: N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
CAS Number: 1259314-65-2
Molecular Formula: C₂₄H₂₆Cl₂N₄
Molecular Weight: 441.40
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-11 00:51:10
Modify Date: 2024-01-16 00:55:01
JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].

Name	N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride
Synonyms	N-[4-(4-Methyl-1-piperazinyl)phenyl]-9-acridinamine dihydrochloride N-[4-(4-Methylpiperazin-1-yl)phenyl]acridin-9-amine dihydrochloride 9-Acridinamine, N-[4-(4-methyl-1-piperazinyl)phenyl]-, hydrochloride (1:2)

Description	JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Kb value (antagonist activity) of 16 nM and a Ki (binding affinity) value of 28 nM[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Neurological Disease
Target	Ki: 28 nM (α2C- adrenoceptor)[2]. Kb: 16 nM (α2C- adrenoceptor)[2].
References	[1]. Tricklebank MD, et al. JP-1302: a new tool to shed light on the roles of alpha2C-adrenoceptors in brain. Br J Pharmacol. 2007 Feb;150(4):381-2. [2]. Sallinen J, et al. Pharmacological characterization and CNS effects of a novel highly selective alpha2C-adrenoceptor antagonist JP-1302. Br J Pharmacol. 2007 Feb;150(4):391-402.