1611489-00-9

1611489-00-9 structure

Name: Benzyl-PEG8-THP
Chemical Name: 2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran
CAS Number: 1611489-00-9
Molecular Formula: C₂₈H₄₈O₁₀
Molecular Weight: 544.675
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-17 23:13:16
Modify Date: 2024-01-08 09:19:58
Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran
Synonyms	MFCD29049395 2-[(1-Phenyl-2,5,8,11,14,17,20,23-octaoxapentacosan-25-yl)oxy]tetrahydro-2H-pyran 2H-Pyran, tetrahydro-2-[(25-phenyl-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl)oxy]- Benzyl-PEG8-THP

Description	Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562