187269-60-9
187269-60-9 structure
- Name: Bimosiamose disodium
- Chemical Name: Bimosiamose disodium
- CAS Number: 187269-60-9
- Molecular Formula: C46H52Na2O16
- Molecular Weight: 906.875
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-06-28 22:05:57
- Modify Date: 2024-01-09 08:35:07
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Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].
| Name | Bimosiamose disodium |
|---|---|
| Synonyms |
[1,1'-Biphenyl]-3-acetic acid, 3',3''-(1,6-hexanediyl)bis[6'-(α-D-mannopyranosyloxy)-, sodium salt (1:2)
Disodium 2,2'-{1,6-hexanediylbis[6'-(α-D-mannopyranosyloxy)-3',3-biphenyldiyl]}diacetate Bimosiamose disodium 7AK2FKB9AW UNII:7AK2FKB9AW |
| Description | Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, P-selectin, and L-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1] |
| In Vitro | Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1]. |
| In Vivo | Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Animal Model: Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1] Dosage: 25 mg/kg Administration: Intravenous injection Result: Showed a significant increase in survival compared with controls. |
| References |
| Molecular Formula | C46H52Na2O16 |
|---|---|
| Molecular Weight | 906.875 |
| Exact Mass | 906.305054 |