217817-01-1
217817-01-1 structure
- Name: Tos-PEG4-Boc
- Chemical Name: 2-Methyl-2-propanyl 3-{2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}propanoate
- CAS Number: 217817-01-1
- Molecular Formula: C20H32O8S
- Molecular Weight: 432.528
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-07-04 15:20:40
- Modify Date: 2024-01-23 18:07:58
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Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1].
| Name | 2-Methyl-2-propanyl 3-{2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}propanoate |
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| Synonyms |
2-Methyl-2-propanyl 3-{2-[2-(2-{[(4-methylphenyl)sulfonyl]oxy}ethoxy)ethoxy]ethoxy}propanoate
Propanoic acid, 3-[2-[2-[2-[[(4-methylphenyl)sulfonyl]oxy]ethoxy]ethoxy]ethoxy]-, 1,1-dimethylethyl ester |
| Description | Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker, which refers to the PEG composition. Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) can be used in the synthesis of a series of PROTACs, such as BI-3663 (HY-111546). BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation, and inhibits PTK2 with an IC50 of 18 nM[1]. |
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| Related Catalog | |
| Target |
PEGs |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 528.5±45.0 °C at 760 mmHg |
| Molecular Formula | C20H32O8S |
| Molecular Weight | 432.528 |
| Flash Point | 273.4±28.7 °C |
| Exact Mass | 432.181793 |
| LogP | 2.09 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.495 |
| Hazard Codes | Xn |
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