943726-01-0

943726-01-0 structure

Name: Propargyl-PEG2-Ms
Chemical Name: 2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate
CAS Number: 943726-01-0
Molecular Formula: C₈H₁₄O₅S
Molecular Weight: 222.259
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-16 12:59:33
Modify Date: 2024-01-20 21:10:03
Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

Name	2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate
Synonyms	2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, methanesulfonate

Description	Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Bai S, et al. Synthesis and structure-activity relationship studies of conformationally flexibletetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 2014 May 22;57(10):4239-51.