Propargyl-PEG2-Ms

Modify Date: 2024-01-20 21:10:03

Propargyl-PEG2-Ms Structure
Propargyl-PEG2-Ms structure
Common Name Propargyl-PEG2-Ms
CAS Number 943726-01-0 Molecular Weight 222.259
Density 1.2±0.1 g/cm3 Boiling Point 358.0±27.0 °C at 760 mmHg
Molecular Formula C8H14O5S Melting Point N/A
MSDS N/A Flash Point 170.3±23.7 °C

 Use of Propargyl-PEG2-Ms


Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate
Synonym More Synonyms

 Propargyl-PEG2-Ms Biological Activity

Description Propargyl-PEG2-Ms is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Bai S, et al. Synthesis and structure-activity relationship studies of conformationally flexibletetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands. J Med Chem. 2014 May 22;57(10):4239-51.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 358.0±27.0 °C at 760 mmHg
Molecular Formula C8H14O5S
Molecular Weight 222.259
Flash Point 170.3±23.7 °C
Exact Mass 222.056198
LogP -0.36
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.464
Storage condition 2-8°C

 Synonyms

2-[2-(2-Propyn-1-yloxy)ethoxy]ethyl methanesulfonate
Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, methanesulfonate