1315380-70-1

1315380-70-1 structure

Name: VU 591 hydrochloride
Chemical Name: 5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)
CAS Number: 1315380-70-1
Molecular Formula: C₁₆H₁₃ClN₆O₅
Molecular Weight: 404.76
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2018-06-14 19:29:38
Modify Date: 2024-01-05 11:26:42
VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].

Name	5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)
Synonyms	1H-Benzimidazole, 2,2'-[oxybis(methylene)]bis[6-nitro-, hydrochloride (1:1) 5-Nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole hydrochloride (1:1)

Description	VU591 hydrochloride is a potent, selective renal outer medullary potassium channel (ROMK or Kir1.1) inhibitor, with an IC50 of 0.24 μM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.24 μM (ROMK)[1].
References	[1]. Bhave G, et al. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Mol Pharmacol. 2011 Jan;79(1):42-50.