1421854-16-1
1421854-16-1 structure
- Name: AC 186
- Chemical Name: AC-186
- CAS Number: 1421854-16-1
- Molecular Formula: C18H17F3O
- Molecular Weight: 306.322
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-07-08 07:10:48
- Modify Date: 2025-08-25 20:16:41
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AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender specific neuroprotection in a Parkinson’s Disease rat model[1].
| Name | AC-186 |
|---|---|
| Synonyms |
4-[4,4-Difluoro-1-(2-fluorophenyl)cyclohexyl]phenol
Phenol, 4-[4,4-difluoro-1-(2-fluorophenyl)cyclohexyl]- AC-186 |
| Description | AC-186 is a selective non-steroidal estrogen receptor β (ERβ) agonist with EC50s of 6 nM and 5000 nM for ERβ and ERα, respectively. AC-186 shows gender specific neuroprotection in a Parkinson’s Disease rat model[1]. |
|---|---|
| Related Catalog | |
| Target |
ERβ:6 nM (EC50) ERα:5000 nM (EC50) |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 396.9±42.0 °C at 760 mmHg |
| Molecular Formula | C18H17F3O |
| Molecular Weight | 306.322 |
| Flash Point | 172.4±22.4 °C |
| Exact Mass | 306.123138 |
| LogP | 4.24 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.566 |