152785-82-5

152785-82-5 structure

Name: (S)-Seco-Duocarmycin SA
Chemical Name: Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate
CAS Number: 152785-82-5
Molecular Formula: C₂₅H₂₄ClN₃O₇
Molecular Weight: 513.927
Catalog: Research Areas Cancer
Create Date: 2018-06-04 00:05:23
Modify Date: 2024-01-03 12:15:26
(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].

Name	Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate
Synonyms	Methyl (8S)-8-(chloromethyl)-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-3,6,7,8-tetrahydropyrrolo[3,2-e]indole-2-carboxylate Pyrrolo[3,2-e]indole-2-carboxylic acid, 8-(chloromethyl)-3,6,7,8-tetrahydro-4-hydroxy-6-[(5,6,7-trimethoxy-1H-indol-2-yl)carbonyl]-, methyl ester, (8S)-

Description	(S)-Seco-Duocarmycin SA is a DNA alkylator, cytotoxic to cancer cells, and acts as a ADC cytotoxin for antibody-drug conjugates[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129(35):10858-69.