1807534-82-2

1807534-82-2 structure

Name: Azido-PEG4-NHS-ester
Chemical Name: 1-[(14-Azido-3,6,9,12-tetraoxatetradecan-1-oyl)oxy]-2,5-pyrrolidinedione
CAS Number: 1807534-82-2
Molecular Formula: C₁₄H₂₂N₄O₈
Molecular Weight: 374.346
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-07-10 11:26:19
Modify Date: 2024-01-03 11:19:54
Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-[(14-Azido-3,6,9,12-tetraoxatetradecan-1-oyl)oxy]-2,5-pyrrolidinedione
Synonyms	1-[(14-Azido-3,6,9,12-tetraoxatetradecan-1-oyl)oxy]-2,5-pyrrolidinedione 2,5-Pyrrolidinedione, 1-[(14-azido-1-oxo-3,6,9,12-tetraoxatetradec-1-yl)oxy]-

Description	Azido-PEG4-NHS-ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562