283167-06-6

283167-06-6 structure

Name: FK962
Chemical Name: N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide
CAS Number: 283167-06-6
Molecular Formula: C₁₄H₁₇FN₂O₂
Molecular Weight: 264.295
Catalog: Research Areas Neurological Disease
Create Date: 2018-07-18 01:55:01
Modify Date: 2024-01-09 14:28:51
FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].

Name	N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide
Synonyms	N-(1-Acetyl-4-piperidinyl)-4-fluorobenzamide N-(1-acetylpiperidin-4-yl)-4-fluorobenzamide Benzamide, N-(1-acetyl-4-piperidinyl)-4-fluoro- MFCD09832545

Description	FK962 is an enhancer of somatostatin release, exerts cognitive-enhancing actions[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	Somatostatin release[1]
In Vitro	FK962 (1 nM-1 μM) significantly enhances high K+-evoked somatostatin release from rat hippocampal slices. FK962 also significantly reduces somatostatin-induced inhibition of Ca2+ channels at 1-100 nM in single rat hippocampal neurons using whole-cell patch-clamp[1].
In Vivo	FK962 (0.1, 0.3 or 1.0 mg/kg; i.p.) and Donepezil (a single dose of 1 mg/kg) act synergistically to improve cognition in rats: as an add-on therapy for Alzheimer's disease[2]. Animal Model: Male Lister Hooded rats, weighing approximately 270-300[2] Dosage: 0.1, 0.3 or 1.0 mg/kg; Donepezil was given as a single dose of 1 mg/kg Administration: Administered i.p. Result: Resulted in minimal cognition enhancement when given separately. Combination showed a significantly greater effect on cognition.
References	[1]. Tokita K, et al. FK962, a novel enhancer of somatostatin release, exerts cognitive-enhancing actions in rats. Eur J Pharmacol. 2005 Dec 19;527(1-3):111-20. [2]. McCarthy AD, et al. FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease. Pharmacol Biochem Behav. 2011 Mar;98(1):76-80.