798577-91-0
798577-91-0 structure
- Name: BAL-27862
- Chemical Name: 3-[(4-{1-[2-(4-Aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile
- CAS Number: 798577-91-0
- Molecular Formula: C20H17N7O2
- Molecular Weight: 387.395
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2018-06-27 19:19:23
- Modify Date: 2025-08-25 05:19:39
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Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division[1][2][3][4].
| Name | 3-[(4-{1-[2-(4-Aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile |
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| Synonyms |
Propanenitrile, 3-[[4-[1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl]-1,2,5-oxadiazol-3-yl]amino]-
MFCD28502222 3-[(4-{1-[2-(4-Aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile |
| Description | Avanbulin (BAL27862) is a potent, Colchicine site-binding, tubulin assembly inhibitor. Avanbulin inhibits tubulin assembly at 37 °C with an IC50 of 1.4 μM. Avanbulin binds to tubulin with an apparent Kd value of 244 nM. Avanbulin can be used for the research of cancer and cell division[1][2][3][4]. |
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| Related Catalog | |
| In Vitro | Avanbulin (0-4 μM) binds to tubulin with an apparent Kd value of 244 nM[1]. Avanbulin (0-20 μM) and Colchicine (0-10 μM) are competitive for binding to tubulin with an apparent Ki value of 1.8 μM[1]. Avanbulin binds to the same site as Colchicine at the intradimer interface[1]. Avanbulin (50 μM; 0, 10, 20, 30, 60 min) induces the proteolysis of tubulin[1]. Avanbulin (1-100 nM; 72 h; HeLa-tubGFP cells) has anti-proliferative effects[1]. Avanbulin (33 nM; 0, 10, 20, 30, 60 min; HeLa-tubGFP cells) collapses the mitotic spindle and forms the tiny tubulin aggregates[1]. Avanbulin does not induce the formation of tubulin oligomers[1]. Avanbulin (0.1 nM-1.0 μM; 96 hours) induces growth inhibition of cells with a median relative IC50 of 13.8 nM[2]. Avanbulin (0-1,000 nM; 3 days) inhibits the growth of glioblastoma cancer stem-like cells, GBM6 (EC50=20.8 nM) and GBM9 (EC50=21.7 nM) [3]. Avanbulin (6 nM and 20 nM) inhibits the migration of GBM6 and GBM9 cells[3]. Avanbulin (6 nM and 20 nM; GBM6-shEB1 and GBM6-sh0 cells) triggers astrocytic differentiation of GBM6 in an EB1-dependent manner[3]. Avanbulin (12 nM; 4 h) reduces kinetochore-microtubule (KT–MT) occupancy of MG132(10 μM; 2h) treated hTert-RPE1 eGFP-α-tubulin cells[4]. Avanbulin (12 nM; 4 h) reduces average inter-KT distances of cells[4]. Avanbulin-treated (12 nM; 4 h) cells show intact spindle morphology and lack of obvious chromosome alignment defects[4]. Cell Cytotoxicity Assay[2] Cell Line: 23 cell lines, including RD, TC-71, SJ-GBM2, NB-1643. Concentration: 0.1 nM-1.0 μM Incubation Time: 96 hours Result: Induced growth inhibition of cells with a median relative IC50 of 13.8 nM. |
| References |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 771.5±70.0 °C at 760 mmHg |
| Molecular Formula | C20H17N7O2 |
| Molecular Weight | 387.395 |
| Flash Point | 420.4±35.7 °C |
| Exact Mass | 387.144379 |
| LogP | 4.25 |
| Vapour Pressure | 0.0±2.6 mmHg at 25°C |
| Index of Refraction | 1.731 |