955371-84-3
955371-84-3 structure
- Name: VK-II-86
- Chemical Name: 4-(9H-Carbazol-4-yloxy)-1-{[2-(2-methoxyphenoxy)ethyl]amino}-2-butanol
- CAS Number: 955371-84-3
- Molecular Formula: C25H28N2O4
- Molecular Weight: 420.501
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-06-26 08:36:59
- Modify Date: 2024-01-09 17:25:09
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VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1].
| Name | 4-(9H-Carbazol-4-yloxy)-1-{[2-(2-methoxyphenoxy)ethyl]amino}-2-butanol |
|---|---|
| Synonyms |
2-Butanol, 4-(9H-carbazol-4-yloxy)-1-[[2-(2-methoxyphenoxy)ethyl]amino]-
4-(9H-Carbazol-4-yloxy)-1-{[2-(2-methoxyphenoxy)ethyl]amino}-2-butanol VK-II-86 |
| Description | VK-II-86 is a Carvedilol (HY-B0006) analogue lacking antagonist activity at β-adrenoceptors, in hypokalaemia. VK-II-86 prevents hypokalaemia-induced ventricular arrhythmia through multi-channel effects. VK-II-86 prevents all hypokalaemia-induced changes in ion channel activity and oxidative stress[1]. |
|---|---|
| Related Catalog | |
| In Vivo | VK-II-86 在低钾血症小鼠全心模型中显著减少非持续性和持续性室性快速心律失常的数量[1]。 |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 660.6±55.0 °C at 760 mmHg |
| Molecular Formula | C25H28N2O4 |
| Molecular Weight | 420.501 |
| Flash Point | 353.3±31.5 °C |
| Exact Mass | 420.204895 |
| LogP | 4.93 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.648 |