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1431291-44-9

1431291-44-9 structure
1431291-44-9 structure
  • Name: Mal-amido-PEG2-TFP ester
  • Chemical Name: 2,3,5,6-Tetrafluorophenyl 3-[2-(2-{[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoate
  • CAS Number: 1431291-44-9
  • Molecular Formula: C20H20F4N2O7
  • Molecular Weight: 476.376
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-01 00:08:21
  • Modify Date: 2024-01-14 21:14:06
  • Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2,3,5,6-Tetrafluorophenyl 3-[2-(2-{[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoate
Synonyms 2,3,5,6-Tetrafluorophenyl 3-[2-(2-{[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoyl]amino}ethoxy)ethoxy]propanoate
Propanoic acid, 3-[2-[2-[[3-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxopropyl]amino]ethoxy]ethoxy]-, 2,3,5,6-tetrafluorophenyl ester
Description Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.4±0.1 g/cm3
Boiling Point 640.1±55.0 °C at 760 mmHg
Molecular Formula C20H20F4N2O7
Molecular Weight 476.376
Flash Point 340.9±31.5 °C
Exact Mass 476.120667
LogP 1.11
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.516