851713-74-1

851713-74-1 structure

Name: Curculigoside C
Chemical Name: 2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 3-hydroxy-2,6-dimethoxybenzoate
CAS Number: 851713-74-1
Molecular Formula: C₂₂H₂₆O₁₂
Molecular Weight: 482.435
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-17 12:29:26
Modify Date: 2024-01-08 23:09:10
Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively[1].

Name	2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 3-hydroxy-2,6-dimethoxybenzoate
Synonyms	2-(β-D-Glucopyranosyloxy)-5-hydroxybenzyl 3-hydroxy-2,6-dimethoxybenzoate Benzoic acid, 3-hydroxy-2,6-dimethoxy-, [2-(β-D-glucopyranosyloxy)-5-hydroxyphenyl]methyl ester Curculigoside C

Description	Curculigoside C is a phenolic glucoside with potent antioxidative and neuroprotective activities. Curculigoside C shows IC50 values of 0.25 mM and 0.88 mM for hydroxyl radicals and superoxide anion radicals, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Curculigoside C 在评估 H2O2[2] 诱导的 SY5Y 细胞死亡中具有神经保护作用。
In Vivo	Curculigoside C (15、30 和 60 mg/kg) 表现出快速的口服吸收（Tmax = 0.106 h、0.111 h 和 0.111 h），高消除（t1/2 = 2.022 h、2.061 h 和 2.048 ）和低绝对生物利用度（分别为 2.01%、2.13% 和 2.39%）[2]。大鼠血浆中 Curculigoside C (CC) 灌胃后的药代动力学参数[1]。
References	[1]. Wu Q, et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1065-7. [2]. Di Wu, et al. Pharmacokinetic and Metabolism Studies of Curculigoside C by UPLC-MS/MS and UPLC-QTOF-MS. Molecules. 2018 Dec 21;24(1):21.

Hazard Codes	Xi