86259-89-4
86259-89-4 structure
- Name: Tos-PEG4-THP
- Chemical Name: 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate
- CAS Number: 86259-89-4
- Molecular Formula: C20H32O8S
- Molecular Weight: 432.528
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-09 21:33:03
- Modify Date: 2024-01-09 16:54:01
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Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].
| Name | 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate |
|---|---|
| Synonyms |
Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 4-methylbenzenesulfonate
MFCD28976701 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate Tos-PEG4-THP |
| Description | Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H32O8S |
| Molecular Weight | 432.528 |
| Flash Point | 288.5±30.1 °C |
| Exact Mass | 432.181793 |
| LogP | 0.65 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.523 |
| Storage condition | 2-8°C |