Tos-PEG4-THP
Modify Date: 2024-01-09 16:54:01
Tos-PEG4-THP structure
|
Common Name | Tos-PEG4-THP | ||
|---|---|---|---|---|
| CAS Number | 86259-89-4 | Molecular Weight | 432.528 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 553.4±50.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O8S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 288.5±30.1 °C | |
Use of Tos-PEG4-THPTos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
| Name | 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate |
|---|---|
| Synonym | More Synonyms |
| Description | Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. Andrew P. Crew, et al. Modulators of proteolysis and associated methods of use. WO2019195609A2. |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 553.4±50.0 °C at 760 mmHg |
| Molecular Formula | C20H32O8S |
| Molecular Weight | 432.528 |
| Flash Point | 288.5±30.1 °C |
| Exact Mass | 432.181793 |
| LogP | 0.65 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.523 |
| Storage condition | 2-8°C |
| Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 4-methylbenzenesulfonate |
| MFCD28976701 |
| 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethyl 4-methylbenzenesulfonate |
| Tos-PEG4-THP |