113104-25-9

113104-25-9 structure

Name: NSC 228155
Chemical Name: 4-Nitro-7-[(1-oxido-2-pyridinyl)sulfanyl]-2,1,3-benzoxadiazole
CAS Number: 113104-25-9
Molecular Formula: C₁₁H₆N₄O₄S
Molecular Weight: 290.255
Catalog: Signaling Pathways Epigenetics Epigenetic Reader Domain
Create Date: 2018-06-10 18:51:32
Modify Date: 2024-01-08 21:43:16
NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].

Name	4-Nitro-7-[(1-oxido-2-pyridinyl)sulfanyl]-2,1,3-benzoxadiazole
Synonyms	4-Nitro-7-[(1-oxido-2-pyridinyl)sulfanyl]-2,1,3-benzoxadiazole 2,1,3-Benzoxadiazole, 4-nitro-7-[(1-oxido-2-pyridinyl)thio]-

Description	NSC 228155 is a potent inhibitor of KIX-KID interaction, inhibits kinase-inducible domain (KID) from CREB and KID-interacting domain (KIX) from CBP, with an IC50 of 0.36 μM. NSC 228155 is not selective against CREB-mediated gene transcription in living HEK 293T cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Acetyltransferase Signaling Pathways >> Epigenetics >> Epigenetic Reader Domain
Target	IC50: 0.36 μM (KIX-KID)[1]
In Vitro	NSC 228155 (Compound 1) inhibits CREB- and VP16-CREB-mediated gene transcription in living HEK 293T cells with an IC50 of 2.09 and 6.14 μM, respectively[1].
References	[1]. Xie F, et al. Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5371-5.