1329802-06-3

1329802-06-3 structure

Name: Memantine-d3 hydrochloride
Chemical Name: 3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)
CAS Number: 1329802-06-3
Molecular Formula: C₁₂H₁₉D₃ClN
Molecular Weight: 218.78
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-06-06 21:22:44
Modify Date: 2024-01-16 19:42:04
Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].

Name	3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)
Synonyms	Tricyclo[3.3.1.13,7]decan-1-amine, 3-methyl-5-(methyl-d3)-, hydrochloride (1:1) 3-Methyl-5-(2H3)methyl-1-adamantanamine hydrochloride (1:1)

Description	Memantine-d3 (hydrochloride) is deuterium labeled Memantine. Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Marotta G, et al. Memantine Derivatives as Multitarget Agents in Alzheimer's Disease. Molecules. 2020;25(17):4005. Published 2020 Sep 2. [3]. Pinho J, et al. Enhanced LTP in aged rats: Detrimental or compensatory?. Neuropharmacology. 2017;114:12-19. [4]. Moriguchi S, et al. Memantine Improves Depressive-like Behaviors via Kir6.1 Channel Inhibition in Olfactory Bulbectomized Mice. Neuroscience. 2020;442:264-273.