1427004-19-0

1427004-19-0 structure

Name: DBCO-PEG4-NHS ester
Chemical Name: 4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide
CAS Number: 1427004-19-0
Molecular Formula: C₃₄H₃₉N₃O₁₀
Molecular Weight: 649.688
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-07 11:14:07
Modify Date: 2024-01-09 09:06:18
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide
Synonyms	Dibenz[b,f]azocine-5(6H)-butanamide, 11,12-didehydro-N-[15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl]-γ-oxo- 4-(11,12-Didehydrodibenzo[b,f]azocin-5(6H)-yl)-N-{15-[(2,5-dioxo-1-pyrrolidinyl)oxy]-15-oxo-3,6,9,12-tetraoxapentadec-1-yl}-4-oxobutanamide

Description	DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562