151135-64-7

151135-64-7 structure

Name: 4'-Hydroxy-2,4-dimethoxychalcone
Chemical Name: (2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
CAS Number: 151135-64-7
Molecular Formula: C₁₇H₁₆O₄
Molecular Weight: 284.306
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-07-17 13:09:48
Modify Date: 2024-01-10 10:29:33
4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].

Name	(2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one
Synonyms	2-Propen-1-one, 3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)- (2E)-3-(2,4-dimethoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one (2E)-3-(2,4-Dimethoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one

Description	4'-Hydroxy-2,4-dimethoxychalcone is a natural chalcone derivatives in the red herbal resin of Dracaena cochinchinensis. 4'-Hydroxy-2,4-dimethoxychalcone displays a wide range of biological activities including antimalarial, antiprotozoal, antibacterial, antifungal activity[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	4'-Hydroxy-2,4-dimethoxychalcone (compound 2) is against P. falciparum D6 (IC50=4.2 μM) and W2 (IC50=4.8 μM)[1].
In Vivo	4'-Hydroxy-2,4-dimethoxychalcone (compound 2; oral; 160 mg/kg) has a T1/2 of 1.94 hours, a Cmax of 158 ng/mL and an AUC of 384 ng•h/mL in four- to five-week-old ICR mice[1].
References	[1]. Clare E Gutteridge, et al. In vitro biotransformation, in vivo efficacy and pharmacokinetics of antimalarial chalcones. Pharmacology. 2011;87(1-2):96-104. [2]. Qing-An Zheng, et al. Flavonoids from the Resin of Dracaena cochinchinensis. Helvetica Chimica Acta, 87(5), 1167–1171.