Name | 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol |
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Synonyms |
14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
MFCD28950782 3,6,9,12-Tetraoxatetradecan-1-ol, 14-amino- |
Description | NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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Related Catalog | |
Target |
PEGs Non-cleavable |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
References |
[2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1. |
Density | 1.1±0.0 g/cm3 |
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Boiling Point | 346.3±0.0 °C at 760 mmHg |
Molecular Formula | C10H23NO5 |
Molecular Weight | 237.293 |
Flash Point | 163.2±0.0 °C |
Exact Mass | 237.157623 |
LogP | -2.44 |
Vapour Pressure | 0.0±0.0 mmHg at 25°C |
Index of Refraction | 1.460 |
Storage condition | 2-8°C |