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34188-11-9

34188-11-9 structure
34188-11-9 structure
  • Name: NH2-PEG5-OH
  • Chemical Name: 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
  • CAS Number: 34188-11-9
  • Molecular Formula: C10H23NO5
  • Molecular Weight: 237.293
  • Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
  • Create Date: 2018-06-26 11:38:08
  • Modify Date: 2024-01-03 18:01:01
  • NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
Synonyms 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol
MFCD28950782
3,6,9,12-Tetraoxatetradecan-1-ol, 14-amino-
Description NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog
Target

PEGs

Non-cleavable

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

[2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1.

Density 1.1±0.0 g/cm3
Boiling Point 346.3±0.0 °C at 760 mmHg
Molecular Formula C10H23NO5
Molecular Weight 237.293
Flash Point 163.2±0.0 °C
Exact Mass 237.157623
LogP -2.44
Vapour Pressure 0.0±0.0 mmHg at 25°C
Index of Refraction 1.460
Storage condition 2-8°C