NH2-PEG5-OH
Modify Date: 2024-01-03 18:01:01
NH2-PEG5-OH structure
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Common Name | NH2-PEG5-OH | ||
|---|---|---|---|---|
| CAS Number | 34188-11-9 | Molecular Weight | 237.293 | |
| Density | 1.1±0.0 g/cm3 | Boiling Point | 346.3±0.0 °C at 760 mmHg | |
| Molecular Formula | C10H23NO5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 163.2±0.0 °C | |
Use of NH2-PEG5-OHNH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol |
|---|---|
| Synonym | More Synonyms |
| Description | NH2-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. NH2-PEG5-OH is also a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Non-cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
[2]. Nianhe Han, et al. Derivatives of dolastatin 10 and uses thereof. WO2016192527A1. |
| Density | 1.1±0.0 g/cm3 |
|---|---|
| Boiling Point | 346.3±0.0 °C at 760 mmHg |
| Molecular Formula | C10H23NO5 |
| Molecular Weight | 237.293 |
| Flash Point | 163.2±0.0 °C |
| Exact Mass | 237.157623 |
| LogP | -2.44 |
| Vapour Pressure | 0.0±0.0 mmHg at 25°C |
| Index of Refraction | 1.460 |
| Storage condition | 2-8°C |
| 14-Amino-3,6,9,12-tetraoxatetradecan-1-ol |
| MFCD28950782 |
| 3,6,9,12-Tetraoxatetradecan-1-ol, 14-amino- |