600171-70-8

600171-70-8 structure

Name: Orphan GPCR SP9155 agonist P550 (mouse, rat)
Chemical Name: L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide
CAS Number: 600171-70-8
Molecular Formula: C₁₂₆H₁₉₅N₃₇O₃₇
Molecular Weight: 2820.122
Catalog: Research Areas Metabolic Disease
Create Date: 2018-06-26 16:28:10
Modify Date: 2025-09-18 23:28:08
Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].

Name	L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-phenylalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide
Synonyms	L-Alanyl-L-serylglycyl-L-prolyl-L-leucylglycyl-L-threonyl-L-leucyl-L-alanyl-L-α-glutamyl-L-α-glutamyl-L-leucyl-L-seryl-L-seryl-L-tyrosyl-L-seryl-L-arginyl-L-arginyl-L-lysylglycylglycyl-L-pheny lalanyl-L-seryl-L-phenylalanyl-L-arginyl-L-phenylalaninamide Orphan GPCR SP9155 Agonist P550 (mouse) trifluoroacetate salt

Description	Orphan GPCR SP9155 agonist P550 (mouse, rat) (26RFa (mouse, rat)), a member of the RFamide peptide family with orexigenic effect, is the cognate ligand of the mouse orphan receptor GPR103, also designated SP9155 or AQ27[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	26RFa is a key neuropeptide in the regulation of energy metabolism[2].
In Vivo	26RFa dose-dependently reduces glucose-induced insulin release, inhibits the insulin responses to both arginine and exendin-4 and did not affect glucagon output in rat pancreas[3].
References	[1]. Chartrel N, et al. Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. Proc Natl Acad Sci U S A. 2003;100(25):15247-15252. [2]. Chartrel N, et al. The Neuropeptide 26RFa (QRFP) and Its Role in the Regulation of Energy Homeostasis: A Mini-Review. Front Neurosci. 2016;10:549. Published 2016 Nov 29. [3]. Egido EM, et al. 26RFa, a novel orexigenic neuropeptide, inhibits insulin secretion in the rat pancreas. Peptides. 2007;28(4):725-730.