DC Chemicals Limited
China
Product Name: TCO-NHS ester
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: TCO-carbonate
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Purity: 98.0%
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Contact: Ms Wang

1191901-33-3

1191901-33-3 structure

1191901-33-3 structure

Name: TCO-NHS ester
Chemical Name: 1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione
CAS Number: 1191901-33-3
Molecular Formula: C₁₃H₁₇NO₅
Molecular Weight: 267.278
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-13 03:36:48
Modify Date: 2024-01-02 18:04:00
TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione
Synonyms	1-({[(4Z)-4-Cycloocten-1-yloxy]carbonyl}oxy)-2,5-pyrrolidinedione 2,5-Pyrrolidinedione, 1-[[[(4Z)-4-cycloocten-1-yloxy]carbonyl]oxy]-

Description	TCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.3±0.1 g/cm3
Boiling Point	369.1±45.0 °C at 760 mmHg
Molecular Formula	C₁₃H₁₇NO₅
Molecular Weight	267.278
Flash Point	177.0±28.7 °C
Exact Mass	267.110687
LogP	1.45
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.540

Hazard Codes	Xi
RIDADR	NONH for all modes of transport