72296-47-0
72296-47-0 structure
- Name: Apovincaminic acid hydrochloride salt
- Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1)
- CAS Number: 72296-47-0
- Molecular Formula: C20H23ClN2O2
- Molecular Weight: 358.862
- Catalog: Research Areas Neurological Disease
- Create Date: 2018-07-10 22:51:38
- Modify Date: 2024-01-09 18:49:53
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Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].
| Name | (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1) |
|---|---|
| Synonyms |
(3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1)
Eburnamenine-14-carboxylic acid, (3α,16α)-, hydrochloride (1:1) |
| Description | Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2]. |
|---|---|
| Related Catalog | |
| In Vivo | Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1]. Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2]. Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1] Dosage: 10 mg/kg Administration: I.p. twice daily for 4 days Result: Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation. |
| References |
| Molecular Formula | C20H23ClN2O2 |
|---|---|
| Molecular Weight | 358.862 |
| Exact Mass | 358.144806 |