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72296-47-0

72296-47-0 structure
72296-47-0 structure
  • Name: Apovincaminic acid hydrochloride salt
  • Chemical Name: (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1)
  • CAS Number: 72296-47-0
  • Molecular Formula: C20H23ClN2O2
  • Molecular Weight: 358.862
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2018-07-10 22:51:38
  • Modify Date: 2025-08-27 13:22:55
  • Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].

Name (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1)
Synonyms (3α,16α)-Eburnamenine-14-carboxylic acid hydrochloride (1:1)
Eburnamenine-14-carboxylic acid, (3α,16α)-, hydrochloride (1:1)
Description Apovincaminic acid hydrochloride salt is an orally active and brain-penetrant main active metabolite of Vinpocetine (VP). Apovincaminic acid hydrochloride salt exerts a neuroprotective type of action[1][2].
Related Catalog
In Vivo Apovincaminic acid (10 mg/kg; i.p. twice daily for 4 days) effectively attenuates the behavioral deficits, and significantly decreases lesion size and the region of microglia activation[1]. Apovincaminic acid (10 mg/kg; p.o.) is absorbed 50% of the dose comparing with i.v. administration in rats[2]. Animal Model: Male Harlan‐Wistar rats (300-400 g) are injected NMDA[1] Dosage: 10 mg/kg Administration: I.p. twice daily for 4 days Result: Attenuated the attention deficit effectively. Prevented the learning and memory impairment in the spontaneous alternation and Morris water maze tests. significantly reduced lesion size microglia activation.
References

[1]. Nyakas C, et, al. Neuroprotective effects of vinpocetine and its major metabolite cis-apovincaminic acid on NMDA-induced neurotoxicity in a rat entorhinal cortex lesion model. CNS Neurosci Ther. Summer 2009;15(2):89-99.

[2]. Pudleiner P, et, al. Study on the absorption of vinpocetine and apovincaminic acid. Eur J Drug Metab Pharmacokinet. Oct-Dec 1993;18(4):317-21.

[3]. Wang M, et, al. Simultaneous Determination of Vinpocetine and its Major Active Metabolite Apovincaminic Acid in Rats by UPLC-MS/MS and its Application to the Brain Tissue Distribution Study. J Chromatogr Sci. 2018 Mar 1;56(3):225-232.

Molecular Formula C20H23ClN2O2
Molecular Weight 358.862
Exact Mass 358.144806
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