350997-39-6

350997-39-6 structure

Name: OGG1-IN-08
Chemical Name: 3,4-Dichloro-1-benzothiophene-2-carbohydrazide
CAS Number: 350997-39-6
Molecular Formula: C₉H₆Cl₂N₂OS
Molecular Weight: 261.128
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-02 20:39:13
Modify Date: 2024-01-16 19:07:29
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].

Name	3,4-Dichloro-1-benzothiophene-2-carbohydrazide
Synonyms	Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide 3,4-Dichloro-1-benzothiophene-2-carbohydrazide

Description	OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
Target	IC50: 0.22 μM (OGG1)[1]
In Vitro	OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1]. OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1]. OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1].
References	[1]. Nathan Donley,et al. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015 Oct 16;10(10):2334-43.