350997-39-6
350997-39-6 structure
- Name: OGG1-IN-08
- Chemical Name: 3,4-Dichloro-1-benzothiophene-2-carbohydrazide
- CAS Number: 350997-39-6
- Molecular Formula: C9H6Cl2N2OS
- Molecular Weight: 261.128
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-06-02 20:39:13
- Modify Date: 2024-01-16 19:07:29
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OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1].
| Name | 3,4-Dichloro-1-benzothiophene-2-carbohydrazide |
|---|---|
| Synonyms |
Benzo[b]thiophene-2-carboxylic acid, 3,4-dichloro-, hydrazide
3,4-Dichloro-1-benzothiophene-2-carbohydrazide |
| Description | OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. OGG1-IN-08 decreases both the glycosylase and lyase activities of OGG1[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.22 μM (OGG1)[1] |
| In Vitro | OGG1-IN-08 (50 μM) inhibits different DNA glycosylases activities, it inhibits nei endonuclease VIII-like 1 DNA glycosylase (NEIL1)(84.56%), endonuclease III-like (NTH1)(63.09%), and Fpg (91.74%), respectively[1]. OGG1-IN-08 (10 μM) has a inhibitory OGG1 lyase activity on a substrate containing an AP site compared with the no inhibitor control[1]. OGG1-IN-08 (10 μM) decreases the number of bases released into solution by OGG1 for both the 8-oxo-Gua and FapyGua compared with the no inhibitor[1]. |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Molecular Formula | C9H6Cl2N2OS |
| Molecular Weight | 261.128 |
| Exact Mass | 259.957794 |
| LogP | 2.34 |
| Index of Refraction | 1.718 |