Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide
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Purity: 98.0%
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Email: enquiry@dycnchem.com

639089-73-9

639089-73-9 structure

Name: N-(4-(4-(3-Methyl-1H-pyrazol-5-ylamino)-6-(4-Methylpiperazin-1-yl)pyrimidin-2-ylthio)phenyl)propionamide
Chemical Name: N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide
CAS Number: 639089-73-9
Molecular Formula: C₂₂H₂₈N₈OS
Molecular Weight: 452.576
Catalog: Signaling Pathways Cell Cycle/DNA Damage Aurora Kinase
Create Date: 2018-07-20 09:33:11
Modify Date: 2024-02-04 13:29:36
VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

Name	N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide
Synonyms	Propanamide, N-[4-[[4-(4-methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl]thio]phenyl]- N-[4-({4-(4-Methyl-1-piperazinyl)-6-[(5-methyl-1H-pyrazol-3-yl)amino]-2-pyrimidinyl}sulfanyl)phenyl]propanamide

Description	VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Aurora Kinase Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Aurora Kinase
References	[1]. Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50(3):518-27. [2]. Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49(3):559-69.