1009376-10-6

1009376-10-6 structure

Name: RTIL 13
Chemical Name: RTIL 13
CAS Number: 1009376-10-6
Molecular Formula: C₃₀H₅₅BrN₂O₃
Molecular Weight: 571.67
Catalog: Signaling Pathways GPCR/G Protein Ras
Create Date: 2018-06-11 02:54:10
Modify Date: 2024-01-10 19:36:04
RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 µM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[1][2].

Name	RTIL 13

Description	RTIL 13 is a potent inhibitor of dynamin GTPase, with an IC50 of 2.3 µM for dynamin I GTPase. RTIL 13 also targets pleckstrin homology lipid binding domain. RTIL 13 can inhibit receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras Research Areas >> Neurological Disease
Target	IC50: 2.3 µM (dynamin I GTPase)[1]
In Vitro	RTIL 13 inhibits receptor-mediated and synaptic vesicle endocytosis, with IC50s of 9.3 μM and 7.1 μM, respectively[2].
References	[1]. Zhang J, et, al. From Spanish fly to room-temperature ionic liquids (RTILs): synthesis, thermal stability and inhibition of dynamin 1 GTPase by a novel class of RTILs. New Journal of Chemistry. 2008 Jan; 32(1): 1-180. [2]. Ascent Scientific Launch Novel Dynamin Inhibitor Dyngo-4a™ with Children's Medical Research Institute and University of Newcastle. Tuesday, December 28, 2021.

Molecular Formula	C₃₀H₅₅BrN₂O₃
Molecular Weight	571.67

Hazard Codes	Xi