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1378531-80-6

1378531-80-6 structure
1378531-80-6 structure
  • Name: DBCO-NHCO-PEG5-NHS ester
  • Chemical Name: DBCO-PEG5-NHS ester
  • CAS Number: 1378531-80-6
  • Molecular Formula: C36H43N3O11
  • Molecular Weight: 693.74012
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-12 19:03:16
  • Modify Date: 2023-01-16 13:33:05
  • DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name DBCO-PEG5-NHS ester
Synonyms MFCD28334547
Description DBCO-NHCO-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C36H43N3O11
Molecular Weight 693.74012