1390641-90-3

1390641-90-3 structure

1390641-90-3 structure

Name: TUG-905
Chemical Name: TUG-905
CAS Number: 1390641-90-3
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways GPCR/G Protein GPR40
Create Date: 2018-06-12 17:29:36
Modify Date: 2024-07-31 21:30:33
TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].

Name	TUG-905

Description	TUG-905 is a potent GPR40 agonist with an pEC50 value of 7.03. TUG-905 increases hypothalamic cell proliferation and survival. TUG-905 reduces body mass and increases the POMC mRNA expression[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> GPR40 Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
Target	pEC50: 7.03 (GPR40)[1]
In Vitro	TUG-905 (10 µM；7、13 天) 促进细胞增殖和增加神经母细胞标记物 DCX mRNA 水平[2]。 TUG-905 (10 µM；2、4、24 小时) 增加 Neuro2a (鼠神经母细胞瘤) 细胞中的 GPR40、BDNF 基因表达[2]。 Western Blot Analysis[2] Cell Line: DCX/GFAP positive cells (neurospheres from mouse hypothalamic tissue) Concentration: 10 µM Incubation Time: 7 days Result: Increased mRNA levels of the neuroblast marker, DCX, as well as the number of DCX-immunopositive cells.
In Vivo	TUG-905 (2.0 μL，1.0 mM；i.c.v.；每天两次，持续 6 天) 可降低体重并表现出减少热量摄入的趋势[1]。 Animal Model: 6 weeks, Male Swiss mice[1] Dosage: 2.0 μL, 1.0 mM Administration: I.c.v.; twice a day for 6 days Result: Reduced body mass and exhibited a trend toward reducing caloric intake, and induced an increase of IL10 and IL6 in the hypothalamus, and increased the POMC mRNA expression.
References	[1]. Dragano NRV, et al. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation. 2017 Apr 26;14(1):91. [2]. Engel DF, et al. Activation of GPR40 induces hypothalamic neurogenesis through p38- and BDNF-dependent mechanisms. Sci Rep. 2020 Jul 6;10(1):11047.

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