1433996-86-1

1433996-86-1 structure

Name: Azido-PEG5-NHS ester
Chemical Name: Azido-PEG5-NHS ester
CAS Number: 1433996-86-1
Molecular Formula: C₁₇H₂₈N₄O₉
Molecular Weight: 432.426
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-15 10:24:06
Modify Date: 2024-01-24 12:24:48
Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Azido-PEG5-NHS ester
Synonyms	AZIDO-PEG5-NHS

Description	Azido-PEG5-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562