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1443467-88-6

1443467-88-6 structure
1443467-88-6 structure
  • Name: Benzyl-PEG3-CH2-Boc
  • Chemical Name: Benzyl-PEG4-CH2CO2tBu
  • CAS Number: 1443467-88-6
  • Molecular Formula: C19H30O6
  • Molecular Weight: 354.438
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-14 15:18:36
  • Modify Date: 2024-02-09 00:08:34
  • Benzyl-PEG3-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

Name Benzyl-PEG4-CH2CO2tBu
Synonyms 2,5,8,11-Tetraoxatridecan-13-oic acid, 1-phenyl-, 1,1-dimethylethyl ester
MFCD28122956
2-Methyl-2-propanyl 1-phenyl-2,5,8,11-tetraoxatridecan-13-oate
Description Benzyl-PEG3-CH2-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Girardini M, et al. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019 Jun 15;27(12):2466-2479.

Density 1.1±0.1 g/cm3
Boiling Point 435.2±35.0 °C at 760 mmHg
Molecular Formula C19H30O6
Molecular Weight 354.438
Flash Point 186.7±26.0 °C
Exact Mass 354.204254
LogP 2.52
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.486
Hazard Codes Xi