146395-14-4

146395-14-4 structure
146395-14-4 structure
  • Name: THP-PEG5-OH
  • Chemical Name: THP-PEG6
  • CAS Number: 146395-14-4
  • Molecular Formula: C15H30O7
  • Molecular Weight: 322.395
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-12-03 19:55:46
  • Modify Date: 2025-08-25 23:41:07
  • THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name THP-PEG6
Synonyms 3,6,9,12-Tetraoxatetradecan-1-ol, 14-[(tetrahydro-2H-pyran-2-yl)oxy]-
14-(Tetrahydro-2H-pyran-2-yloxy)-3,6,9,12-tetraoxatetradecan-1-ol
MFCD26793753
Description THP-PEG5-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density 1.1±0.1 g/cm3
Boiling Point 432.5±45.0 °C at 760 mmHg
Molecular Formula C15H30O7
Molecular Weight 322.395
Flash Point 215.4±28.7 °C
Exact Mass 322.199158
LogP -1.82
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.469
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