1807539-06-5

1807539-06-5 structure

Name: Acid-PEG3-C2-Boc
Chemical Name: Acid-PEG3-t-butyl ester
CAS Number: 1807539-06-5
Molecular Formula: C₁₄H₂₆O₇
Molecular Weight: 306.352
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-08 12:56:24
Modify Date: 2025-08-31 12:37:28
Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

Name	Acid-PEG3-t-butyl ester
Synonyms	2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid MFCD28015771 3,7,10,13-Tetraoxahexadecan-16-oic acid, 2,2-dimethyl-4-oxo-

Description	Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1. [2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.