1807539-06-5
1807539-06-5 structure
- Name: Acid-PEG3-C2-Boc
- Chemical Name: Acid-PEG3-t-butyl ester
- CAS Number: 1807539-06-5
- Molecular Formula: C14H26O7
- Molecular Weight: 306.352
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-08 12:56:24
- Modify Date: 2024-01-23 08:12:16
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Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
| Name | Acid-PEG3-t-butyl ester |
|---|---|
| Synonyms |
2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid
MFCD28015771 3,7,10,13-Tetraoxahexadecan-16-oic acid, 2,2-dimethyl-4-oxo- |
| Description | Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PEGs Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1. |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 423.2±35.0 °C at 760 mmHg |
| Molecular Formula | C14H26O7 |
| Molecular Weight | 306.352 |
| Flash Point | 147.2±19.4 °C |
| Exact Mass | 306.167847 |
| LogP | 0.50 |
| Vapour Pressure | 0.0±2.2 mmHg at 25°C |
| Index of Refraction | 1.457 |
| Storage condition | 2-8°C |