Acid-PEG3-C2-Boc

Modify Date: 2024-01-23 08:12:16

Acid-PEG3-C2-Boc Structure
Acid-PEG3-C2-Boc structure
Common Name Acid-PEG3-C2-Boc
CAS Number 1807539-06-5 Molecular Weight 306.352
Density 1.1±0.1 g/cm3 Boiling Point 423.2±35.0 °C at 760 mmHg
Molecular Formula C14H26O7 Melting Point N/A
MSDS N/A Flash Point 147.2±19.4 °C

 Use of Acid-PEG3-C2-Boc


Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].

 Names

Name Acid-PEG3-t-butyl ester
Synonym More Synonyms

 Acid-PEG3-C2-Boc Biological Activity

Description Acid-PEG3-C2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs for the degradation of EGFR and inhibition of mTOR[1][2].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References

[1]. Nathanael Gray, et al. Bifunctional molecules for degradation of egfr and methods of use. WO2017185036A1.

[2]. Christopher Semko, et al. Rapamycin analogs as mtor inhibitors. WO 2018204416 A1.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 423.2±35.0 °C at 760 mmHg
Molecular Formula C14H26O7
Molecular Weight 306.352
Flash Point 147.2±19.4 °C
Exact Mass 306.167847
LogP 0.50
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.457
Storage condition 2-8°C

 Synonyms

2,2-Dimethyl-4-oxo-3,7,10,13-tetraoxahexadecan-16-oic acid
MFCD28015771
3,7,10,13-Tetraoxahexadecan-16-oic acid, 2,2-dimethyl-4-oxo-
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