Shanghai Nianxing Industrial Co., Ltd
China
Product Name: CX 717
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

DC Chemicals Limited
China
Product Name: CX 717
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

867276-98-0

867276-98-0 structure

867276-98-0 structure

Name: CX 717
Chemical Name: CX717
CAS Number: 867276-98-0
Molecular Formula: C₁₁H₁₁N₃O₃
Molecular Weight: 233.223
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2018-06-06 14:45:21
Modify Date: 2024-01-05 21:16:54
CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD)[1][2].

Name	CX717
Synonyms	2,1,3-Benzoxadiazol-5-yl(4-morpholinyl)methanone Methanone, 2,1,3-benzoxadiazol-5-yl-4-morpholinyl-

Description	CX 717 is a positive allosteric modulator of AMPA receptor. Antidepressant-like effect. CX 717 can be used for the research of adult attention deficit hyperactivity disorder (ADHD)[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vivo	CX 717 (CX717; 20 mg/kg) has a rapid (30 min) but short-lasting (up to 24 h) antidepressantlike effect in the forced swim test.CX 717 also produces a rapid (up to 1 h) increase of brain-derived neurotrophic factor (BDNF) and a more sustained (up to 6 h) increase of p11[2]. Intra-cortical infusion of CX 717 (85 mM) increases the efflux of noradrenaline, dopamine, and serotonin, but not glutamate[2]. Animal Model: Male Sprague-Dawley rats weighing 280-350 g[2] Dosage: 20 mg/kg (administered at 1 mL/kg) Administration: Intraperitoneal (i.p.) injection Result: Evoked antidepressant-like effects (20 mg/kg, i.p.) did not alter the extracellular concentrations of noradrenaline (NA), dopamine (DA), serotonin (5-HT) and glutamate in the medial prefrontal cortex (mPFC).
References	[1]. Linda J Porrino, et al. Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates. PLoS Biol. 2005 Sep;3(9):e299. [2]. Marta Gordillo-Salas, et al. Antidepressant-Like Effects of CX717, a Positive Allosteric Modulator of AMPA Receptors. Mol Neurobiol. 2020 Aug;57(8):3498-3507.

Density	1.4±0.1 g/cm3
Boiling Point	422.1±55.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₁N₃O₃
Molecular Weight	233.223
Flash Point	209.1±31.5 °C
Exact Mass	233.080048
LogP	-0.64
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.623