870640-62-3

870640-62-3 structure

Name: Monomethyl auristatin E intermediate-11
Chemical Name: (2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol
CAS Number: 870640-62-3
Molecular Formula: C₁₄H₂₃NO
Molecular Weight: 221.33852
Catalog: Research Areas Cancer
Create Date: 2018-10-07 10:34:17
Modify Date: 2024-01-17 01:53:10
Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].

Name	(2S,3S)-2-(benzyl(methyl)amino)-3-methylpentan-1-ol

Description	Monomethyl auristatin E intermediate-11 is an intermediate reactant in the synthesis of Monomethyl auristatin E (HY-15162). Monomethyl auristatin E (MMAE) is a microtubule/tubulin inhibitor with anticancer activity. MMAE is widely used as the cytotoxic component (ADC Cytotoxin) of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Lisa Buckel, et al. Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. Cancer Res. 2015 Apr 1;75(7):1376-87.

Molecular Formula	C₁₄H₂₃NO
Molecular Weight	221.33852