927822-45-5
927822-45-5 structure
- Name: Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-
- Chemical Name: Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]-
- CAS Number: 927822-45-5
- Molecular Formula: C16H17N5O4
- Molecular Weight: 343.33728
- Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
- Create Date: 2018-07-11 06:18:01
- Modify Date: 2024-01-10 10:23:03
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UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule[1][2].
| Name | Benzaldehyde, 4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]- |
|---|
| Description | UC-1V150 is a specific TLR7 (Toll-like receptor) agonist that stimulates cellular immune responses and has anti-tumor activity. UC-1V150 can be used to synthesize ISAC (Immune-Stimulating Antibody Conjugates) molecule[1][2]. |
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| Related Catalog | |
| Target |
TLR7 |
| In Vitro | UC-1V150 (0.01-10 μM, 24 hour) can stimulate the release of IL-6 and IL-2 cytokines effectively in bone-marrow-derived macrophages[1]. UC-1V150 (1 μg/mL, 48 hours) can increase the expression of FcγRIIA and FcγRIII while inducing an approximately 1.5-fold increase in macrophage phagocytosis index of target cells in hman monocyte-derived macrophages (hMDM)[2]. |
| In Vivo | UC-1V150 (intravenous injection, 0.38-38 nM, once, 2 hours) effectively induces release of serum cytokines within a certain concentration range in female C57BL/6 mice (5-6 weeks of age)[1]. Animal Model: Female C57BL/6 mice (5–6 weeks of age)[1] Dosage: 0.38-38 nM Administration: Intravenous injection; once; 2 hours Result: Induced serum cytokine IL-6 levels about 0.1 ng/mL and IL-2 levels about 1.5 ng/mL at the concentration of 38 nM. |
| References |
| Molecular Formula | C16H17N5O4 |
|---|---|
| Molecular Weight | 343.33728 |