933054-33-2

933054-33-2 structure

Name: Monomethyl lithospermate
Chemical Name: Monomethyl lithospermate
CAS Number: 933054-33-2
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways PI3K/Akt/mTOR Akt
Create Date: 2019-01-17 12:34:30
Modify Date: 2024-01-19 23:38:10
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS)[1].

Name	Monomethyl lithospermate

Description	Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS)[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Neurological Disease
In Vitro	Monomethyl lithospermate (5、10 和 20 μM; 12 h) 提高氧-葡萄糖剥夺和再灌注 (OGD/R) 处理的 SHSY-5Y 细胞的细胞活力[1]。 Monomethyl lithospermate (20 μM; 12 h) 可减轻 SHSY-5Y 细胞在缺氧、葡萄糖剥夺/复氧后的细胞损伤、线粒体膜电位损失和细胞凋亡[1]。 Monomethyl lithospermate (5、10 和 20 μM; 12 h) 减少 SHSY-5Y 细胞的 ROS 和细胞内氧化应激[1]。 Monomethyl lithospermate (20 μM; 12 h) 可激活 SHSY-5Y 细胞的 PI3K/AKT[1]。 Immunofluorescence[1] Cell Line: SHSY-5Y cells Concentration: 5, 10, and 20 μM Incubation Time: 12 hours Result: Inhibited the mitochondrial membrane potential (MMOP) collapse and apoptosis of SHSY-5Y cells induced by oxygen and glucose deprivation/Reoxygenation (OGD/R) treatment.
In Vivo	Monomethyl lithospermate (72.4 μM/kg; 口服; 每日 1 次, 连续 14 天) 改善改善缺血再灌注 (IR) 24 h 后中动脉闭塞 (MCAO) 大鼠的神经功能，减少脑梗死面积；可降低 MCAO 大鼠氧化应激水平，抑制神经元凋亡[1]。 Monomethyl lithospermate 通过激活 PI3K/AKT 改善缺血-再灌注诱导的神经损伤[1]。
References	[1]. Yang F, et al. Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling. Front Pharmacol. 2022 Oct 13;13:1024439.

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